Proteomics

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MARK2 serves as a key regulator of host antiviral immunity through GEF-H1 phosphorylation at Ser645 in a microtubule-dependent manner


ABSTRACT: Wang et al. identify MARK2 as a key regulator of innate antiviral immunity. The phosphorylation of GEF-H1 at Ser645 by MARK2 enhances TBK1 activation and induces IFN-β and interferon-stimulated genes. This establishes the MARK2–GEF-H1–TBK1 axis as a fundamental component of host antiviral defense.

ORGANISM(S): Homo Sapiens

SUBMITTER: Sidong Xiong  

PROVIDER: PXD071998 | iProX | Mon Dec 15 00:00:00 GMT 2025

REPOSITORIES: iProX

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