Dataset Information

Mechanisms of Etomidate Addiction and Neuro-Hepatic Toxicity: Molecular Pathway Analysis Based on Multi-Omics Integration

ABSTRACT: This dataset contains brain and liver multi-omics data from male SPF C57BL/6 mice exposed to etomidate or vehicle (35% propylene glycol). Mice were assigned to five groups: chronic control (vehicle, 14 days), low-dose (etomidate 3 mg/kg, 14 days), high-dose (etomidate 6 mg/kg, 14 days), acute control (single vehicle), and acute-death (single etomidate 100 mg/kg). Brain and liver tissues were collected for DIA-based quantitative proteomics (Bruker nanoElute 2 + timsTOF Pro 2, DIA-PASEF; Spectronaut v19) and PRM validation (SpectroDive), and for untargeted metabolomics (UHPLC-Q-TOF, AB SCIEX TripleTOF 5600; mzXML + XCMS).

ORGANISM(S): Mus Musculus

SUBMITTER: Peng Zhang

PROVIDER: PXD072375 | iProX | Wed Dec 24 00:00:00 GMT 2025

REPOSITORIES: iProX

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Dataset Information

Mechanisms of Etomidate Addiction and Neuro-Hepatic Toxicity: Molecular Pathway Analysis Based on Multi-Omics Integration

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