Dataset Information
Proteomic IP-MS analysis of Asprosin/PFKP in regulating cardiac hypertrophy model
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Yan Zhang
PROVIDER: PXD072385 | iProX | Wed Dec 24 00:00:00 GMT 2025
REPOSITORIES: iProX
Publications
YY1/Asprosin/PFKP axis regulates glycolytic metabolic and exacerbates pathological cardiac hypertrophy.
Nature communications 20260401
In hypertrophic and failing hearts, fuel metabolism is reprogrammed toward enhanced glycolysis. Here, we identify asprosin, an adipokine, as a critical regulator of this process in pathological cardiac hypertrophy. In patients, circulating asprosin levels correlate with NT-proBNP and EF. Cardiomyocyte-specific asprosin overexpression aggravates hypertrophy, abnormal glycolysis, and impairs mitochondrial ATP production in male mice, whereas its deficiency confers protection against TAC- or Ang II ...[more]
