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Intradermal Delivery of Catalase via Extracellular Vesicles for Targeted Photoaging Therapy

ABSTRACT: We engineered a 313-cell line to produce EVs that were subsequently loaded with catalase (CAT), a key antioxidant enzyme. These CAT-loaded EVs (313EVs) exhibited high loading efficiency and maintained both vesicle integrity and enzymatic activity

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Zhaogang Yang

PROVIDER: PXD072392 | iProX | Fri Dec 12 00:00:00 GMT 2025

REPOSITORIES: iProX

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Intradermal Delivery of Catalase via Extracellular Vesicles for Targeted Photoaging Therapy.

Zhang Pengchen P Pan Bo B Chen Jiayi J Jiang Hao H Wang Xinhe X Chen Yiyou Y Wang Wei W Li Ming M Zeng Qingyu Q Yang Zhaogang Z

Biomaterials research 20260318

The therapeutic potential of protein-based drugs is often limited by challenges in delivery, including instability, rapid degradation, and poor tissue targeting. Extracellular vesicles (EVs), as naturally derived nanocarriers, offer distinct advantages including biocompatibility, low immunogenicity, and efficient intercellular communication. Here, we engineered a 313 cell line to stably produce catalase (CAT)-loaded EVs (313EVs) that maintained vesicle integrity, exhibited high loading efficienc ...[more]

PMID: 41859756

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Intradermal Delivery of Catalase via Extracellular Vesicles for Targeted Photoaging Therapy(in vitro)

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