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Defective O-fucosylation of EDIL3 attenuates invasion and vascular remodeling of trophoblasts via LIFR signaling pathway in preeclampsia

ABSTRACT: Preeclampsia(PE)is a severe placental disorder that affects 3%-5% of all pregnancies worldwide. The primary cause of PE is abnormal placentationduring eanly pregnancy, including poor trophoblast invasion and insutficientapiral arteriole remodeling, Protein O-ucosylation is a type of protein posttranslational modification that is catalyzed by Protein O-fucosy'ltransferase(poFUT). However, the role and underlying mechanisms of protein O-fucosylation and poFUT1 in PE remain elusive.

ORGANISM(S): Homo Sapiens

SUBMITTER: Shuai Liu

PROVIDER: PXD072416 | iProX | Thu Dec 25 00:00:00 GMT 2025

REPOSITORIES: iProX

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Defective O-fucosylation of EDIL3 attenuates invasion and vascular remodeling of trophoblasts via LIFR signaling pathway in preeclampsia.

Li Yaqi Y Wu Hongpan H Lei Yuyu Y Bai Shuyu S Wang Jiao J Yan Bin B Liu Yubo Y Liu Shuai S

Nature communications 20260513

Preeclampsia (PE) is a severe pregnancy disorder caused by placental dysfunction. Protein O-fucosylation is a type of protein post translational modification that is catalyzed by protein O-fucosyltransferases (poFUTs). However, the role and underlying mechanisms of O-fucosylation/poFUT1 in PE remain elusive. Here, we revealed a lower level of poFUT1 in the plasma and placental tissues of PE patients than in normal pregnancy (NP) women. Moreover, poFUT1 deletion induced PE-like phenotypes in a mo ...[more]

PMID: 42129223

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