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Crocins ameliorate experimental immune checkpoint inhibitor-related myocarditis by targeting the Hpx/Nrf2/HO-1 pathway

ABSTRACT: Immune checkpoint inhibitors (ICIs) for cancer therapy may induce immune-related adverse events including myocarditis, which occurs infrequently but carries a high mortality rate. Crocins are the active constituents derived from Crocus sativus L. (Saffron), and have demonstrated various bioactivities including anti-tumor, anti-inflammation, anti-oxidation, anti-ischemia, anti-aging, and neuroprotection.

ORGANISM(S): Mus Musculus

SUBMITTER: Hongjun Yang

PROVIDER: PXD072469 | iProX | Sat Dec 27 00:00:00 GMT 2025

REPOSITORIES: iProX

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