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Antibacterial and Anti-virulence Activity of the Repurposed Agent SX-682 Against Staphylococcus aureus

ABSTRACT: Proteomics of Staphylococcus aureus SA113 after treatment with SX - 682

ORGANISM(S): Staphylococcus Aureus Subsp. Aureus Nctc 8325

SUBMITTER: Zhijian Yu

PROVIDER: PXD072538 | iProX | Wed Dec 31 00:00:00 GMT 2025

REPOSITORIES: iProX

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Antibacterial and anti-virulence activity of the repurposed agent SX-682 against Staphylococcus aureus.

Wang Haining H Ma Junhua J Chen Chengchun C Xia Yuqing Y Chai Bao B Yu Zhijian Z Wen Zewen Z Li Guiqiu G Wei Ying Y

BMC microbiology 20260509

<h4>Background</h4>Methicillin-resistant Staphylococcus aureus (MRSA) has become one of the most prevalent drug-resistant pathogens in many countries, posing a serious threat to global healthcare. Consequently, there is an urgent need to develop novel antibacterial agents.<h4>Objectives</h4>This study aimed to evaluate the antibacterial and antibiofilm activities of SX-682-an orally bioavailable allosteric inhibitor of CXCR1/2-against S. aureus and to elucidate its underlying mechanisms.<h4>Resu ...[more]

PMID: 42106635

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