CRL4AMBRA1 mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer
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ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Yudong Wang
PROVIDER: PXD072904 | iProX | Thu Jan 08 00:00:00 GMT 2026
REPOSITORIES: iProX
Publications
CRL4<sup>AMBRA1</sup>-mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer.
Sheng Yaru Y Ni Ting T Ding Xiaoyi X Huang Jiaying J Zhao Xueya X Li Xinyao X Li Qingting Q Wang Jing J Yang Xiaoming X Zhang Lin L Zheng Xuan X Cao Dan D Su Rongjia R Lu Xiaojing X Hou Jin J Wang Yudong Y
International journal of biological sciences 20260501 9
Medroxyprogesterone acetate (MPA) is a major fertility-preserving therapeutic option for patients with endometrial cancer (EC); however, MPA resistance markedly restricts the efficacy of conservative treatments. Downregulation of the progesterone receptor (PR) expression is a key determinant of MPA resistance; however, the underlying molecular mechanisms have not been elucidated comprehensively. In this study, we identified AMBRA1, a substrate-specific adaptor of CUL4-RING E3 ubiquitin ligase (C ...[more]
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