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Taurine attenuates arsenic-induced neurotoxicity through modulation of gut microbiota structure

ABSTRACT: This project presents a label-free LC–MS/MS-based proteomic analysis of brain tissue samples from Mus musculus. Brain tissues were collected from three mice per experimental group, yielding a total of nine samples. Proteomic profiling was performed to investigate molecular alterations associated with arsenic-induced neurotoxicity and the neuroprotective effects of taurine treatment. Raw mass spectrometry data and corresponding identification results are provided to support protein identification and quantitative analysis.

ORGANISM(S): Mus Musculus

SUBMITTER: Hongyi Qi

PROVIDER: PXD072922 | iProX | Sun Jan 11 00:00:00 GMT 2026

REPOSITORIES: iProX

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Taurine attenuates arsenic-induced neurotoxicity through modulation of gut microbiota structure.

Zhang Haonan H Qiao Wenjin W Tai Dapeng D Lv Yuan Y Qi Hongyi H

Psychopharmacology 20260219

RATIONALE: Memory decline (MD) and anxiety/depression-like behavior (ADB) are multisystem diseases involving gastrointestinal and microbiota dysbiosis. Long-term exposure to arsenic (As) has been shown to induce MD and ADB; however, the underlying mechanisms remain unknown. Research findings suggest that taurine exhibits protective effects by regulating gut microbiota composition. OBJECTIVE: To investigate the effects of taurine on alterations in gut microbiota, serum metabolites, brain tissue m ...[more]

PMID: 41711907

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Project description:Background: Metabolic dysregulation has been implicated in bronchopulmonary dysplasia development. Taurine is an essential amino acid for neonates and is critically involved in glucose and fatty acid metabolism. Neonatal tissue obtains taurine mainly through the taurine transporter. The biological role of taurine in neonatal lung development has never been explored. As glucose metabolism mechanistically modulates angiogenesis and angiogenesis is the central player for neonatal lung development, we hypothesize that taurine depletion contributes to bronchopulmonary dysplasia development. Results: Although most genes and proteins for oxidative phosphorylation were enriched in hyperoxia pup lungs, the complex-1 activity decreased. The decrease in taurine-dependent complex-1 core subunits, ND5 and ND6, in hyperoxia lungs reasonably explained the discrepancy. Metabolomics analysis demonstrated decreased lung taurine with increased blood taurine of hyperoxia pups, compatible with the decreased taurine transporter expression. Decreased glycosylation and increased degradation explained the decreased taurine transporter expression. The results of the complementary study using tunicamycin and tauroursodeoxycholic acid studies supported that endoplasmic reticulum stress contributes to decreased taurine transporter expression in hyperoxia lungs. The effect of taurine treatment on reducing endoplasmic reticulum stress, increasing ND5 and ND6 expression, angiogenesis, and, most importantly, the alveolar formation is beneficial to hyperoxia rat pups. Conclusion: Hyperoxia exposure causes endoplasmic reticulum stress, increases taurine transporter degradation, and leads to taurine depletion in the neonatal lungs with subsequent metabolic dysregulation, resulting in poor alveolar formation of the neonatal lungs. We provide evidence of the never-being-reported protective role of taurine in neonatal lung development. The fact that taurine attenuates the severity of bronchopulmonary dysplasia by reducing hyperoxia-induced endoplasmic reticulum stress and mitochondrial dysfunction indicates its therapeutic potential for treating bronchopulmonary dysplasia.

Dataset Information

Taurine attenuates arsenic-induced neurotoxicity through modulation of gut microbiota structure

Publications

Taurine attenuates arsenic-induced neurotoxicity through modulation of gut microbiota structure.

Similar Datasets

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