Dataset Information
SC-43 Inhibits Methicillin-resistant Staphylococcus aureus Through Inhibition of Heme Biosynthesis
Ontology highlight
ABSTRACT:
ORGANISM(S): Staphylococcus Aureus
SUBMITTER: 
Wei Huang
PROVIDER: PXD073397 | iProX | Thu Jan 22 00:00:00 GMT 2026
REPOSITORIES: iProX
Publications
SHP-1 agonist SC-43 limits methicillin-resistant Staphylococcus aureus infection through inhibition of heme biosynthesis.
EMBO molecular medicine 20260410 5
The limitations of existing drugs and the development of drug resistance make it urgent to develop new drugs against methicillin-resistant Staphylococcus aureus (MRSA). The re-development of the antibacterial activity of drugs that have already been proven safe for human use is an effective way. In this study, we discovered that the Src homology region 2 domain-containing phosphatase-1 (SHP-1) agonist SC-43, exhibits potent activity against Gram-positive bacteria, including MRSA. The mode of act ...[more]
