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MLS0315771 S. aureus YUSA145 proteomics

ABSTRACT: Quantitative label-free proteomic analysis investigated the global proteomic response of S. aureus YUSA145 treated with 1/2 × MIC MLS0315771 during the exponential growth phase. The results were obtained after performing principal component analysis (PCA) on the raw data and excluding two replicates that showed substantial variation.

ORGANISM(S): Staphylococcus Aureus

SUBMITTER: Zhijian Yu

PROVIDER: PXD073535 | iProX | Sat Jan 24 00:00:00 GMT 2026

REPOSITORIES: iProX

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Drug repurposing: antimicrobial and antibiofilm effects of MLS0315771 against Gram-positive bacteria.

Xu Zhichao Z Tang Yuanyuan Y Ma Junhua J Li Peiyu P Wen Zewen Z Yu Zhijian Z Bai Bing B Chen Zhong Z Han Shiqing S Hou Tieying T

BMC microbiology 20260429 1

The escalating prevalence of multidrug-resistant (MDR) and biofilm-forming Staphylococcus aureus has created an urgent demand for alternative therapeutic strategies beyond conventional antibiotics. In this study, we report for the first time the notable antibacterial and antibiofilm activities of MLS0315771, a competitive phosphomannose isomerase (MPI) inhibitor, against a broad range of Gram-positive bacteria. MLS0315771 exhibited notable inhibitory and bactericidal effects against Staphylococc ...[more]

PMID: 42056861

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