Dataset Information
Antifungal potential of naphthoquinone derivatives: Screening of shikonin-based compounds and mechanistic insights into 5,8-dihydroxy-1,4-naphthoquinone against Candida albicans in vitro and in vivo
Ontology highlight
ABSTRACT:
ORGANISM(S): Candida Albicans
SUBMITTER: 
Yonghua Yang
PROVIDER: PXD073742 | iProX | Wed Jan 28 00:00:00 GMT 2026
REPOSITORIES: iProX
Publications
Antifungal potential of naphthoquinone derivatives: screening of shikonin-based compounds and mechanistic insights into 5,8-dihydroxy-1,4-naphthoquinone against <i>Candida albicans in vitro</i> and <i>in vivo</i>.
Microbiology spectrum 20260227 4
Invasive fungal infections (IFIs), predominantly caused by <i>Candida albicans</i>, are a significant threat to immunocompromised individuals. The emergence of drug-resistant strains has intensified the need for novel antifungal agents. Natural naphthoquinones, including 5,8-dihydroxy-1,4-naphthoquinone (DHNQ, also as PNP-02), have broad-spectrum antimicrobial properties, but their antifungal potential against <i>C. albicans</i> remains underexplored. This study evaluates the antifungal activity ...[more]
