ARIH1 mediates PRDX4 ubiquitination

ABSTRACT: To determine the ubiquitinated sites on PRDX4, we analyzed ubiquitinated PRDX4 via MS, revealing modifications at six lysine residues. Point mutation analysis confirmed that K265 residue is the primary site for ARIH1-mediated PRDX4 ubiquitination. The K265 mutation (K265R) almost abolished PRDX4 ubiquitination in vitro, confirming the critical role of this residue in regulating PRDX4 ubiquitination.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yaoyang Zhang  

PROVIDER: PXD073745 | iProX | Thu Jan 29 00:00:00 GMT 2026

REPOSITORIES: iProX