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Targeted Inhibition of Bacterial Repair by Nitrite-Derived Reactive Nitrogen Species Improves UVC Disinfection Efficiency

ABSTRACT: This proteomics study analyzed E. coli samples from different treatment groups (UVC alone and sequential UVA - UVC with nitrite) to explore how the combined treatment suppresses bacterial repair mechanisms.

ORGANISM(S): Escherichia Coli

SUBMITTER: Jie Hou

PROVIDER: PXD073828 | iProX | Fri Jan 30 00:00:00 GMT 2026

REPOSITORIES: iProX

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Targeted Inhibition of Bacterial Repair by Nitrite-Derived Reactive Nitrogen Species Improves UVC Disinfection Efficiency.

Xu Juchen J Dai Xinru X Wang Jie J Lv Yabing Y Zhang Min M He Xugang X Hou Jie J

Environmental science & technology 20260629 27

UVC irradiation is widely used for disinfection, yet its efficacy is sometimes compromised by bacterial photoreactivation and dark repair. This study demonstrates that pre-exposure to UVA irradiation in the presence of environmentally relevant nitrite (NO2-) significantly suppresses both repair pathways during subsequent UVC treatment. At 1.0 mg-N L-1 NO2- and 612 mJ cm-2 UVA, sequential (UVA-UVC)/NO2- treatm ...[more]

PMID: 42374668

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