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Mass spectrometry identification results of host proteins interacting with the NS1 protein of influenza B virus BYam-2018

ABSTRACT: Mass spectrometry identification results of host proteins interacting with the NS1 protein of influenza B virus BYam-2018

ORGANISM(S): Homo Sapiens

SUBMITTER: Lei Sun

PROVIDER: PXD074269 | iProX | Mon Feb 09 00:00:00 GMT 2026

REPOSITORIES: iProX

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A single mutation in nonstructural protein 1 is critical for the adaptive evolution of influenza B virus.

Jiao Pengtao P Jia Xiaoxiao X Bai Xiaoyuan X Zhao Yuna Y Lin Runshan R Fan Zeqiu Z Fan Wenhui W Zhang He H Li Heqiao H Bi Yuhai Y Wang Dayan D Liu Wenjun W Sun Lei L

Nature communications 20260302 1

Influenza B virus (IBV) has circulated in the human population for a long time, yet the evolutionary mechanisms responsible for host adaptation remain poorly understood. Here we show that recent IBV strains exhibit an enhanced ability to evade the innate immune response and an increased replication efficiency compared with earlier strains. Our data indicate that the nonstructural protein 1 (NS1) of recent IBV strains interacts with TUFM and LC3B to induce mitophagy, leading to degradation of MAV ...[more]

PMID: 41771888

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