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Mass spectrometry-based proteomics screening identifies an IgA–C3 complex associated with disease progression in IgA nephropathy

ABSTRACT: IgA1 immune complexes (IgA1-ICs) containing galactose-deficient IgA1 (GdIgA1) play a critical role in the formation of renal immune deposits in IgA nephropathy (IgAN). Previously, we found that patients with IgA myeloma (IgAMM) without renal IgA deposition exhibit unexpectedly elevated plasma levels of GdIgA1 and poly-IgA complexes. Despite these insights, the pathogenic O-glycosylation profile of IgA and the molecular composition of circulating IgA1-ICs in IgAN remain incompletely characterized.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yong Zhang

PROVIDER: PXD075587 | iProX | Fri Mar 13 00:00:00 GMT 2026

REPOSITORIES: iProX

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