Metabolic-engineered probiotic- OMVs as nanovaccine mediating sequential immunomodulation for chronic bone infection immunotherapy

ABSTRACT: Lei et al. screen out Lactococcus lactis OMVs (Lac-OMVs) and develop metabolic-engineered NAD+-Lac-OMVs nanovaccine with potent tissue repair therapeutic effect. NAD+-Lac-OMVs sequentially activate dendritic cells by membrane component and reprogram inflammatory macrophages for anti-inflammation and bone repair by interior nicotinamide metabolites.

ORGANISM(S): Mus Musculus

SUBMITTER: Cao Yang  

PROVIDER: PXD076052 | iProX | Mon Mar 23 00:00:00 GMT 2026

REPOSITORIES: iProX