Immune surveillance on the insect body surface recognizes a pathogen‑derived fungal protease to activate defenses
Ontology highlight
ABSTRACT:
ORGANISM(S): Locusta Migratoria Manilensis
SUBMITTER: 
Jun Li
PROVIDER: PXD076064 | iProX | Tue Mar 24 00:00:00 GMT 2026
REPOSITORIES: iProX
Publications
Immune surveillance on the insect body surface recognizes a pathogen-derived fungal protease to activate defenses.
Li Jun J Xiao Qi Q Ligoxygakis Petros P Xia Yuxian Y
Nature communications 20260509
Immune systems must distinguish between pathogens and commensals to mount effective responses. However, how hosts discriminate among fungi at surface barriers is largely unknown. Here, we report a surveillance mechanism on the locust body surface that couples general fungal recognition with pathogen-specific activation. The host immulectin-1 (IML1) binds surface-exposed fungal mannans, but immune activation requires cleavage by fungal protease SP28 to release bioactive peptide. The protease is f ...[more]
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