Dataset Information
HERC4 suppresses colorectal cancer progression by promoting STAT3 ubiquitination
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Zilong Zhang
PROVIDER: PXD076133 | iProX | Tue Mar 24 00:00:00 GMT 2026
REPOSITORIES: iProX
Publications
HERC4 suppresses colorectal cancer progression by promoting STAT3 ubiquitination.
iScience 20260611 6
Ubiquitination, a critical post-translational modification, regulates diverse cellular processes including protein degradation, signal transduction, and cell cycle progression. Dysregulation of the ubiquitin system is closely associated with tumor development and progression. HERC4, a member of the HECT-type E3 ubiquitin ligase family, remains poorly characterized in colorectal cancer (CRC). In this study, we report that HERC4 is significantly downregulated in CRC tissues and is associated with ...[more]
