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Phosphatidylserine-Modified Self-Assembling Peptide Nanocarrier Enables Sustained FGF18 Delivery and Restores Mitochondrial Homeostasis for Cartilage Regeneration in Knee Osteoarthritis

ABSTRACT: Knee osteoarthritis (KOA) remains a major clinical challenge due to the limited regenerative capacity of articular cartilage and the poor stability and bioavailability of therapeutic growth factors. In this study, we engineered a phosphatidylserine (PS)-modified RADA16-I self-assembling peptide nanocarrier for the encapsulation and sustained intra-articular delivery of fibroblast growth factor 18 (FGF18). Nuclear magnetic resonance (NMR)

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Jiawei Du

PROVIDER: PXD076843 | iProX | Thu Apr 09 00:00:00 BST 2026

REPOSITORIES: iProX

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Project description:Background: Meniscus tears are the most common injury in the knee and are associated with an increased risk of osteoarthritis (OA). The molecular profile of knees with meniscus tears is not well-studied. Therefore, to advance our understanding of the early response of the knee to injury, we compared the gene expression profile of meniscus and articular cartilage within the same knees following meniscus injury. Hypothesis/Purpose: To identify differences between the molecular signatures of meniscus and articular cartilage from knees with intact articular cartilage undergoing arthroscopic partial meniscectomy. Study Design: Descriptive laboratory study Methods: Patients (n=12) with a known isolated medial meniscus tear without any knee chondrosis or radiographic OA were consented prior to surgery. During arthroscopic partial meniscectomy, a sample of their injured meniscus and a sample of their articular cartilage off the medial femoral condyle were procured. The transcriptome signatures, as measured through Affymetrix microarray, were compared between the two tissues and underlying biological processes were explored computationally. Results: 3566 gene transcripts were differentially expressed between meniscus and articular cartilage. Gene transcripts down-regulated in articular cartilage were associated with extracellular matrix organization, wound healing, cell adhesion, and chemotaxis. Gene transcripts up-regulated in articular cartilage were associated with blood vessels morphogenesis and angiogenesis. Examples of individual genes with significant differences in expression between the two tissues include IBSP (23.76 fold; P < 0.001), upregulated in meniscus, and TREM1 (3.23 fold; P = 0.006), upregulated in meniscus. Conclusion: The meniscus and articular cartilage have distinct gene expression profiles in knees with meniscus tears and intact articular cartilage. Total RNA obtained from injured meniscus and normal articular cartilage from patients undergoing partial meniscectomy.

Dataset Information

Phosphatidylserine-Modified Self-Assembling Peptide Nanocarrier Enables Sustained FGF18 Delivery and Restores Mitochondrial Homeostasis for Cartilage Regeneration in Knee Osteoarthritis

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