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Effect of knocking out TP53 in cancer-associated fibroblasts in hepatocellular carcinoma on the expression of exosome proteins

ABSTRACT: To examine the impact of TP53 knockout in cancer-associated fibroblasts on the progression of liver cancer, we conducted a study wherein cancer-associated fibroblasts were collected and subjected to TP53 knockout. Subsequently, we isolated exosomes secreted by these cells and performed proteomic analysis to assess changes in exosomal protein expression.

ORGANISM(S): Mus Musculus

SUBMITTER: Zengbin Wang

PROVIDER: PXD077102 | iProX | Mon Apr 13 00:00:00 BST 2026

REPOSITORIES: iProX

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