Nociceptive neurons inhibit neutrophil extracellular trap formation via MLKL-licensed histone release
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Yazhou Wang
PROVIDER: PXD077273 | iProX | Thu Apr 16 00:00:00 GMT+01:00 2026
REPOSITORIES: iProX
Publications
Nociceptive neurons inhibit neutrophil extracellular trap formation via MLKL-licensed histone release.
Meng Han H Hu Wenchao W Kang Enming E Xu Qing Q Wang Pengfei P Yi Xuyang X Mao Honghui H Zhang Bowen B Meng Xinyu X Wang Yanjin Y Tan Yanchen Y Mao Zhuqing Z Zheng Xingxing X Niu Lina L Shi Ming M Luo Ceng C Wu Shengxi S Xie Rougang R Wang Yazhou Y
Cell reports 20260601 6
Neutrophil-involved neuroinflammation in dorsal root ganglion (DRG) plays double-sword roles in chronic pain. How DRG neuron-neutrophil interaction contributes to chronic pain remains unclear. Here, we report that MLKL, a key molecule in necroptosis, is constitutively expressed in the nucleus of nociceptive neurons and binds to histone H3. Periphery inflammation disrupted MLKL/H3 interaction, leading to cytoplasmic translocation of MLKL and release of histone H3. Extracellular histone H3 induces ...[more]
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