Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Analysis Report on Chemical Components and Blood-Entering Components of BSHX

ABSTRACT: Chemical Component Identification of the "BSHX" Based on UHPLC-Q-Orbitrap HRMS Technology

ORGANISM(S): Gynochthodes Officinalis Glycyrrhiza Uralensis Angelica Dahurica Var. Formosana Cuscuta Chinensis Var. Chinensis Astragalus Mongholicus Var. Dahuricus Rehmannia Glutinosa Ligusticum Chuanxiong Achyranthes Bidentata

SUBMITTER: Xiaole Zhang

PROVIDER: PXD077284 | iProX | Thu Apr 16 00:00:00 GMT+01:00 2026

REPOSITORIES: iProX

ACCESS DATA

Json Xml

Publications

Rubiadin, as a key metabolite of the Bushen Huoxue formula, promotes apoptosis of endometrial stromal cells and improves intrauterine adhesions by activating the AMPK/p53/p21 pathway.

Shen Cong C Sha Chenyang C Yang Mengqi M Lin Yi Y Ma Juanjuan J Shen Dongyi D Zhang Baohua B Qi Cong C Zhang Qinhua Q Zhang Xiaole X

Frontiers in pharmacology 20260424

<h4>Background</h4><i>The Bushen Huoxue formula (BSHX)</i> is a classic traditional Chinese medicine prescription for treating gynecological disorders. However, its specific metabolites and mechanisms against IUA remain to be elucidated.<h4>Aim</h4>This study aimed to identify the key metabolite of BSHX and to investigate its therapeutic effects and underlying mechanism against IUA, both <i>in vitro</i> and <i>in vivo</i>.<h4>Methods</h4>Network pharmacology and molecular dynamics simulation wer ...[more]

PMID: 42110558

Similar Datasets

Homo sapiens

Project description:etabolomics and Lipidomics of Plasma Biomarkers for Tuberculosis Diagnostics using UHPLC-HRMS (PRJCA041719)

| PRJDB37149 | ENA

Single cell landscape of transdifferentiation using chemical components

Project description:We construct a time-series atlas of in vitro mouse cell transdifferentiating atlas (MCTA) using chemical components, to reveal the gene regulatory networks which govern lineage development.

2025-03-21 | GSE179357 | GEO

Single cell landscape of transdifferentiation using chemical components

Project description:Single cell landscape of transdifferentiation using chemical components

| PRJNA743338 | ENA

Chemical induction of hepatocyte revitalization in mouse hepatocytes [RNA-seq 2]

Project description:We examined how each chemical contributed to hepatocyte revitalization by removing each component of the 5C induction cocktail individually. We then compared deach chemical contributed to hepatocyte revitalization by removing each component of the 5C induction cocktail individually

2023-11-21 | GSE233082 | GEO

GNPS-fenziwangluo-hezao-20240614-neg

Project description:Ecklonia cava UHPLC-Q-Orbitrap HRMS Identification of compounds Component characterization

2024-06-13 | MSV000095031 | GNPS

Ze-qi decoction inhibits neutrophil extracellular trap formation to suppress the progression and metastasis of non-small-cell lung cancer

Project description:Non-small cell lung cancer (NSCLC) research has been exploring complementary and well-established methods with clear mechanisms and less toxicity. Immune dysregulation is vital in the growth and metastasis of NSCLC. Although Ze-qi decoction (ZQD) exhibits therapeutic efficacy in patients with NSCLC, the specific mechanisms remain unclear. UPLC-HRMS was used to identify the primary chemical components. The potent molecular mechanisms were analyzed using network pharmacology and transcriptomic technology. The underlying molecular mechanisms were further investigated in vivo experiments. UPLC-HRMS revealed that 297 bioactive compounds were absorbed into the blood. Combined with the pharmacological analysis, liquiritigenin, vibsanin B, and 11-keto-beta-boswellic acid were revealed as potential active ingredients. Pharmacological analysis and transcriptomic profile indicated neutrophil extracellular trap (NET) formation as the anti-NSCLC target of ZQD. In vivo, ZQD hindered neutrophil recruitment and activation by decreasing hypoxia-inducible factor-1α, CD18, and Intercellular adhesion molecule-1 levels and suppressed NET formation, as evidenced by the downregulated biomarkers. These results were confirmed in the lung metastasis model.

2026-02-25 | GSE304015 | GEO

Human blood LC-MSMS Simple Protein Identification Report

Project description:The present study employs Liquid Chromatography-Mass Spectrometry (LC-MS) technology for the identification of proteins, utilizing the Q-Exactive mass spectrometer produced by Thermo Fisher Scientific. Upon the analysis of the ARP1-USP13-OE sample via Proteome Discoverer software, a total of 3631 peptides were matched, corresponding to the identification of 690 distinct proteins. Subsequent analysis of the ARP1-WT sample with the same software revealed 4326 matched peptides, culminating in the identification of 760 proteins.

2025-05-13 | PXD057487 | Pride

chemical production metagenome

Project description:chemical production metagenome Metagenome

| PRJNA664624 | ENA

Chemical reprogramming of human blood cells into hCiPS cells

Project description:Chemical reprogramming of human blood cells into hCiPS cells

| PRJNA1284192 | ENA

Comparison of gene expression in whole blood of mice subjected to chemical hypoxia in vivo.

Project description:To understand hypoxia mediated changes in whole blood, normal C57Bl/10 mice were gradually exposed to a chronic chemical hypoxic environment, for 2 weeks. Control, age-machted mice were maintained under normoxic conditions. Purpose: To examine and characterize the expression profile of genes expressed at chemical hypoxia of whole blood in comparison to the control. Methods: At the beginning of the experiment mice were divided into two groups, control (room condition) and chemical hypoxic (room condition). For conditioning, the chemical hypoxic group was supplemented with 200ng of CoCl2 per 100ml/day. Animalâs weight and food intake were monitored daily. Food and water were changed daily during the course of the experiment. Before and after the experiments the hematocrit was monitored by taking blood from the tail vein of control and hypoxic animals. After 15 days animals were euthanized using CO2 after whole blood extraction from V. Cava for further analysis. RNA from whole blood was isolated, processed and used for microarray-based expression profiling. Profiles were generated for genes differentially expressed at control versus chemical hypoxia in whole blood using a false discovery rate (FDR) of 0%.We validated the profiles by real-time quantitative reverse transcription-polymerase chain reaction (qPCR). Results: The regional transcriptomes associated with chemical hypoxia in whole blood were identified. We found 3094 genes that were differentially expressed in chemical hypoxic whole blood compared to control with a 0% FDR and a 2 fold cutoff. Conclusion: Transcriptome level differences exist between control and chemical hypoxia in whole blood. Our definition of the synaptic transcriptome provides insight into the functioning of the unique response to hypoxia in whole blood.

2010-05-07 | E-GEOD-15902 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data