Proteomics

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Identification of SNHG9-binding proteins in Huh7 cells using RNA pull-down assay

ABSTRACT: This project aims to identify the specific proteins interacting with lncRNA SNHG9 in hepatoma cells. We performed RNA pull-down assays using biotin-labeled SNHG9 probes in Huh7 cell lysates, followed by mass spectrometry (LC-MS/MS) to analyze the pulled-down protein.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yuhao Wang  

PROVIDER: PXD077375 | iProX | Mon Apr 20 00:00:00 GMT+01:00 2026

REPOSITORIES: iProX

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Publications

Drug-induced liver injury (DILI) is a leading cause of acute liver failure, posing a significant public health burden. Emerging evidence underscores the gut microbiota as a critical environmental factor that profoundly influences liver function and DILI progression, yet the underlying mechanisms remain poorly understood. Here, we identify hepatic long non-coding RNA SNHG9 as a key mediator linking the gut microbiota to acetaminophen (APAP)-induced liver injury. Upregulation of hepatic SNHG9 prot  ...[more]

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