Physical exercise in combination with audiovisual stimulation alleviates cognitive and affective impairments in Alzheimer's disease model mice

ABSTRACT: This project focus on the proteomic changes in AD model mice. AD model mice were established by injecting Aβ₄₂ oligomers into the hippocampus. These mice were then subjected to treadmill training(ADE), 40 Hz audio-visual stimulation(ADVL), or a combination of these interventions(ADEVL). Quantitative proteomics, combined with behavioral tests and molecular analyses, were utilized to evaluate the underlying therapeutic mechanisms of these multimodal interventions in the Aβ₄₂-induced AD model.

ORGANISM(S): Mus Musculus

SUBMITTER: Shujun Xu  

PROVIDER: PXD077685 | iProX | Mon Apr 27 00:00:00 GMT+01:00 2026

REPOSITORIES: iProX