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Synthetic Polymers Remodeling the ECM Microenvironment to Promote Bone Regeneration

ABSTRACT: The advance in materials has played a crucial role in bone regeneration. However, most existing bone repair materials lack the ability to support vital cell behaviors such as cell adhesion, proliferation, and migration due to their bioinert nature. To address this, we design and synthesize a series of cationic-amphiphilic poly(2-oxazoline)s that mimic osteoblast adhesion peptides. The optimal candidate performs as well as the RGD peptide in promoting osteoblast adhesion. Unlike RGD that directly binds to integrin, this polymer adsorbs endogenous ECM proteins and utilizes the RGD sequences within these proteins to mediate integrin-dependent cell adhesion. In addition, this polymer actively stimulates cells to secrete additional ECM components, thereby establishing a positive feedback loop to promote both cell adhesion and ECM protein secretion. Moreover, poly(2-oxazoline)s demonstrates potent in vivo osteogenic activity in a rat skull defect model. Considering that poly(2-oxazoline)s can be easily synthesized in large quantity and resist to proteolysis, the ECM peptide-mimicking poly(2-oxazoline)s offer great potential as emerging biomaterials to promote cell adhesion and bone regeneration.

ORGANISM(S): Mus Musculus

SUBMITTER: Runhui Liu

PROVIDER: PXD078062 | iProX | Tue May 05 00:00:00 BST 2026

REPOSITORIES: iProX

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