Detection of STAT3 ubiquitination modification sites
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Zilong Zhang
PROVIDER: PXD078167 | iProX | Thu May 07 00:00:00 GMT+01:00 2026
REPOSITORIES: iProX
Publications
HERC4 suppresses colorectal cancer progression by promoting STAT3 ubiquitination.
Jiang Lanzhu L Qin Kaidi K Jin Yuan Y Zhu Tong T Xie Tianci T Yin Lanlan L Deng Yu Y Hu Fayong F Wu Qi Q Zhang Zilong Z
iScience 20260611 6
Ubiquitination, a critical post-translational modification, regulates diverse cellular processes including protein degradation, signal transduction, and cell cycle progression. Dysregulation of the ubiquitin system is closely associated with tumor development and progression. HERC4, a member of the HECT-type E3 ubiquitin ligase family, remains poorly characterized in colorectal cancer (CRC). In this study, we report that HERC4 is significantly downregulated in CRC tissues and is associated with ...[more]
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