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Lyn attenuates cisplatin-induced acute kidney injury by inhibition of RIPK1-mediated apoptosis and necroptosis

ABSTRACT: Our study revealed that Lyn protects from cisplatin-induced nephrotoxicity by suppressing RIPK1-mediated apoptosis, necroptosis and inflammation.

ORGANISM(S): Mus Musculus

SUBMITTER: Juan Tang

PROVIDER: PXD078460 | iProX | Sat May 16 00:00:00 GMT+01:00 2026

REPOSITORIES: iProX

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Lyn attenuates cisplatin-induced acute kidney injury by inhibition of RIPK1-mediated apoptosis and necroptosis.

Li Nannan N Zhang Hao H Peng Lingfeng L Liu Jishi J Lin Guoxin G Sun Jian J Li Wei W Hu Jing J Tang Juan J

Biochemical pharmacology 20260521 Pt 1

Cisplatin-induced acute kidney injury (CP-AKI) often limits its clinical utility in treating various solid tumors. However, the underlying pathogenesis of CP-AKI is still unclear. Lyn, a member of Src family kinases, is predominantly implicated in regulating immune response and inflammation. This study investigates the functional role of Lyn in CP-AKI, as well as the possible mechanism. Here, we found that Lyn was down-regulated in mice with CP-AKI. Knockout of Lyn exacerbated renal damage, incr ...[more]

PMID: 42173409

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