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B7-H3 interactome in HaCaT cells by IP/MS

ABSTRACT: Immunoprecipitation coupled with mass spectrometry (IP/MS) was performed in HaCaT cells using an anti-B7-H3 antibody to identify B7-H3-interacting proteins. Raw mass spectrometry data are provided.

ORGANISM(S): Homo Sapiens

SUBMITTER: Lei Cao

PROVIDER: PXD078471 | iProX | Mon May 18 00:00:00 GMT+01:00 2026

REPOSITORIES: iProX

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B7-H3 promotes skin photodamage through ITGA2-NRF2-TFAM-mediated mitochondrial oxidative stress.

Jia Yuanyuan Y Zhang Qiange Q Su Fangying F Zhu Yuan Y Chen Siji S Yang Jingyi J Mao Qiuyu Q Zhang Yiwen Y Yang Yuting Y Ding Sisi S Liu Cuiping C Zhang Xueguang X Luo Dan D Min Wei W Cao Lei L

Communications biology 20260528 1

Ultraviolet radiation (UVR) exposure drives skin photodamage, which constitutes the fundamental basis of both photoaging and photocarcinogenesis, by disrupting mitochondrial homeostasis and inducing reactive oxygen species (ROS) accumulation. Although B7-H3 (CD276) is recognized as an immune-checkpoint molecule involved in tumor metabolism, its role in UVR-induced cutaneous photodamage and the associated redox imbalance remains undefined. Here we show that B7-H3 is elevated in acute and chronic ...[more]

PMID: 42209773

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