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KAT8-mediated PCBP1 acetylation drives neutrophil recruitment in papain-induced airway inflammation

ABSTRACT: Emerging evidence implicates KAT8 as a critical modulator of inflammatory responses in lung diseases. Bosch et al. reported that MG149, a KAT8 inhibitor, reduces pro-inflammatory gene expression in lipopolysaccharide (LPS)-stimulated murine lung slices. Additionally, Liu et al. demonstrated that KAT8 promotes the cleavage and release of IL-33 through direct acetylation in airway epithelial cells in asthma models. However, KAT8 regulatory mechanism remains unexplored. To elucidate the molecular mechanism by which KAT8 modulates chemokine expression, we performed immunoprecipitation followed by mass spectrometry (IP-MS) to identify KAT8-interacting proteins. KEGG pathway enrichment analysis of the top 300 proteins with the highest coverage revealed significant enrichment in RNA binding and mRNA processing pathways, identifying these proteins as potential KAT8-interacting partners.

ORGANISM(S): Homo Sapiens

SUBMITTER: Ruina Huang

PROVIDER: PXD078474 | iProX | Mon May 18 00:00:00 GMT+01:00 2026

REPOSITORIES: iProX

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