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Proteomic Profiling of Inflammatory versus Noninflammatory Cartilage Regions in Knee Osteoarthritis Patients

ABSTRACT: This study performed data-independent acquisition (DIA)-based quantitative proteomic analysis on paired cartilage samples from inflammatory and noninflammatory regions of knee osteoarthritis (OA) patients. The objective was to characterize the proteomic alterations associated with cartilage inflammation and degeneration in OA, and to elucidate the functional connections between oral-gut microbiota dysbiosis and joint pathological changes through multiomics integration.

ORGANISM(S): Homo Sapiens

SUBMITTER: Jinhua Gong

PROVIDER: PXD078593 | iProX | Tue May 19 00:00:00 GMT+01:00 2026

REPOSITORIES: iProX

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The oral-gut-joint axis in osteoarthritis: a multiomics case-control study.

Liu Yuchi Y Gong Jinhua J Zhang Yuying Y Wang Hongyu H Feng Haotian H

Frontiers in cellular and infection microbiology 20260622

<h4>Background</h4>Osteoarthritis (OA) is a globally prevalent degenerative joint disorder that imposes significant socioeconomic burdens. While traditionally viewed as a localized "wear-and-tear" disease, emerging evidence supports a systemic pathogenesis involving the gut-joint axis. The oral-gut-joint pathway remains underexplored in OA pathophysiology.<h4>Objective</h4>This study aimed to characterize oral and gut microbiota signatures in OA patients and elucidate their functional connection ...[more]

PMID: 42440607

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