Proteomics

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LISS enables immune evasion of colorectal cancers irrespective of MSI status

ABSTRACT: LISS enables immune evasion of colorectal cancers irrespective of MSI status

ORGANISM(S): Homo Sapiens

SUBMITTER: Ying Hu  

PROVIDER: PXD078805 | iProX | Mon May 25 00:00:00 BST 2026

REPOSITORIES: iProX

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Despite being hailed as a significant advancement in cancer treatment, immune checkpoint blockade (ICB) has not yielded favorable outcomes in colorectal cancer, both in approximately 85% of cases characterized by microsatellite stability (MSS) and approximately 50% of microsatellite instability (MSI) cases. How ICB efficiency in colorectal cancer treatment can be improved remains unclear. Here, we identify a new immunoregulatory long non-coding RNA (lncRNA) gene named lncRNA of IFN-γ-signaling s  ...[more]

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