Proteomics

Dataset Information

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4D-DIA proteomics analysis of lung tissues before and after intervention with honeysuckle polyphenols in mice with acute lung injury

ABSTRACT: A total of 8,473 proteins were identified, with 1,558 proteins sub-jected to quantitative analysis. Using the above criteria of fold-change thresholds of 1.2 (upregulation) and 0.83 (downregulation), 328 differentially expressed proteins (DEPs) were identified , of which 156 were downregulated and 172 were upregulated. Additionally, GO and KEGG enrichment analyses were conducted to collectively characterize the 328 DEPs. The vast majority of GO biological process (BP) terms are related to inflammatory responses and oxidative stress, such as antigenic-induced acute inflammatory reaction, positive regula-tion of hydrogen peroxide catabolic process, and nitric oxide transport. Notably, the GO cellular component (CC) and molecular function (MF) categories highlighted key terms in-cluding hemoglobin interaction and Toll-like receptor 4 (TLR4) binding, both of which are implicated in inflammatory response and oxidative stress.

ORGANISM(S): Mus Musculus

SUBMITTER: Jinqian Yu  

PROVIDER: PXD079738 | iProX | Mon Jun 15 00:00:00 BST 2026

REPOSITORIES: iProX

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Publications

<i>Lonicerae japonicae flos</i> Polyphenols Attenuate Inflammation-Related Ferroptosis and Gut Microbiota Dysbiosis in LPS-Induced Acute Lung Injury in Mice.

Guo Yingjian Y   Wang Chuangchuang C   Dong Hongjing H   Li Tao T   Kang Chuanzhi C   Wang Xiao X   Yu Jinqian J  

Nutrients 20260623 13

<b>Background/Objectives</b>: Acute lung injury (ALI) currently lacks safe and effective therapeutic strategies with low toxicity. <i>Lonicerae japonicae flos</i>, a traditional herb and functional food, contains polyphenols as its principal active components. This study investigated whether <i>Lonicerae japonicae flos</i> polyphenols (LJP) could exert protective effects against lipopolysaccharide (LPS)-induced ALI in mice. <b>Methods</b>: Eighty-four male C57BL/6J mice were randomly divided int  ...[more]

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