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Endothelial FGF13 impairs angiogenesis by accelerating oxygen-independent HIF-1α degradation

ABSTRACT: Anti-Flag antibody was added to the lysate of HUVECs transfected with Flag-FGF13 for co-immunoprecipitation, and IgG was used as a negative control. LC-MS/MS analysis was carried out by PTM Bio Co., Ltd (Zhejiang, China). The substrate proteins that may bind to FGF13 were screened out according to the score and Flag/IgG ratio of the detected proteins in the mass spectrometry data.

ORGANISM(S): Homo Sapiens

SUBMITTER: Weitao Cong

PROVIDER: PXD079802 | iProX | Tue Jun 16 00:00:00 GMT+01:00 2026

REPOSITORIES: iProX

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Endothelial FGF13 impairs angiogenesis by accelerating oxygen-independent HIF-1α degradation.

Wu Zhaohang Z Chen Yingyun Y Tang Zhouhao Z Jiang Meifan M Zheng Yeyi Y Han Jiming J Hu Zhicheng Z Wu Yiqiang Y Liang Jiaqi J Li Xiang X Xiao Mengyao M Liu Wenya W Jiang Chunhui C Li Xiaokun X Jin Litai L Cong Weitao W

Cell reports 20260713 7

Angiogenesis is a tightly regulated process essential for both development and disease, yet the role of fibroblast growth factor 13 (FGF13) in vascular remodeling has remained unclear. Here, we identify FGF13 as a key negative regulator of physiological and pathological angiogenesis. Using endothelial cell-specific knockout and overexpression mouse models, combined with retinal vascularization assays, hindlimb ischemia and myocardial infarction models, and in vitro endothelial cell functional as ...[more]

PMID: 42441400

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