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MS/MS Analysis of Mouse Condensing and Elongating Spermatid Proteins

ABSTRACT: Through TMT-based quantitative proteomic profiling of mouse condensing and elongating spermatids, we identified 3,901 proteins and applied GO annotation to screen for hydrolase-related candidates. Among 51 candidate hydrolases, five proteins showed nuclear localization annotations, suggesting that a subset of nuclear hydrolytic enzymes may participate in the regulation of spermiogenic chromatin remodeling. These findings provide a candidate framework for exploring enzymes that potentially mediate chromatin protein turnover, protamine maturation, and sperm nuclear condensation during late spermiogenesis.

ORGANISM(S): Mus <genus>

SUBMITTER: Mingxi Liu

PROVIDER: PXD080924 | iProX | Thu Jul 09 00:00:00 GMT+01:00 2026

REPOSITORIES: iProX

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