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Proteomic profiling of ischemic penumbral tissue after head-down positioning intervention in a rat model of ischemic stroke

ABSTRACT: Ischemic stroke is a major cause of neurological disability. Head-down positioning (HDP) has been proposed as a simple non-pharmacological intervention to improve cerebral perfusion after ischemic stroke. In this study, label-free quantitative proteomics was performed to characterize protein alterations associated with ischemic injury and HDP-mediated neuroprotection. Ischemic penumbral tissues were collected from male Sprague-Dawley rats subjected to middle cerebral artery occlusion (MCAO) followed by HDP intervention.

ORGANISM(S): Rattus Rattus

SUBMITTER: Yujuan Li

PROVIDER: PXD081029 | iProX | Tue Jul 14 00:00:00 BST 2026

REPOSITORIES: iProX

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