Dissection of In Vivo Archaeal RNA Polymerase Assembly Reveals a Modular Pathway and Stoichiometric Control

ABSTRACT: These findings establish a modular and hierarchical framework for archaeal RNAP assembly, uncover key regulatory checkpoints, and demonstrate the essential role of small subunit stoichiometry. Given the shared subcomplex architecture and assembly logic, these insights not only fill a longstanding knowledge gap in archaeal RNAP assembly but also illuminate its evolutionary continuity with bacterial and eukaryotic systems and uncover regulatory vulnerabilities with potential applied relevance.

ORGANISM(S): Methanococcus Maripaludis X1

SUBMITTER: Jie Li  

PROVIDER: PXD081683 | iProX | Mon Jul 27 00:00:00 GMT+01:00 2026

REPOSITORIES: iProX