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PY-IP of Colorectal cancer cells

ABSTRACT: Phosphotyrosine status were compared between colorectal cancer cells which is sensitive or resistant to Cetuximab. Activated kinases in resistant cells were examined as targets to overcome the resistance.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Takeshi Tomonaga

PROVIDER: PXD005839 | JPOST Repository | Sun Oct 08 00:00:00 BST 2017

REPOSITORIES: jPOST

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Deep Phospho- and Phosphotyrosine Proteomics Identified Active Kinases and Phosphorylation Networks in Colorectal Cancer Cell Lines Resistant to Cetuximab.

Abe Yuichi Y Nagano Maiko M Kuga Takahisa T Tada Asa A Isoyama Junko J Adachi Jun J Tomonaga Takeshi T

Scientific reports 20170905 1

Abnormality in cellular phosphorylation is closely related to oncogenesis. Thus, kinase inhibitors, especially tyrosine kinase inhibitors (TKIs), have been developed as anti-cancer drugs. Genomic analyses have been used in research on TKI sensitivity, but some types of TKI resistance have been unclassifiable by genomic data. Therefore, global proteomic analysis, especially phosphotyrosine (pY) proteomic analysis, could contribute to predict TKI sensitivity and overcome TKI-resistant cancer. In t ...[more]

PMID: 28874695

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