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Cyclophilin B deficiency causes abnormal dentin collagen matrix

ABSTRACT: To evaluate the effects of cyclophilin B deficiency on expression levels of collagen family members in dentin, we performed protein identification of cyclophilin B-WT, -Het, and -KO teeth after trypsin digestion.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Mitsuo Yamauchi

PROVIDER: PXD006021 | JPOST Repository | Thu Jul 20 00:00:00 BST 2017

REPOSITORIES: jPOST

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Cyclophilin B Deficiency Causes Abnormal Dentin Collagen Matrix.

Terajima Masahiko M Taga Yuki Y Cabral Wayne A WA Nagasawa Masako M Sumida Noriko N Hattori Shunji S Marini Joan C JC Yamauchi Mitsuo M

Journal of proteome research 20170725 8

Cyclophilin B (CypB) is an endoplasmic reticulum-resident protein that regulates collagen folding, and also contributes to prolyl 3-hydroxylation (P3H) and lysine (Lys) hydroxylation of collagen. In this study, we characterized dentin type I collagen in CypB null (KO) mice, a model of recessive osteogenesis imperfecta type IX, and compared to those of wild-type (WT) and heterozygous (Het) mice. Mass spectrometric analysis demonstrated that the extent of P3H in KO collagen was significantly dimin ...[more]

PMID: 28696707

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