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Mitotic chromosome scaffold

ABSTRACT: Quantitative proteomics analysis of mitotic chromosome scaffold based on SILAC

ORGANISM(S): Gallus Gallus

SUBMITTER: Shinya Ohta

PROVIDER: PXD007269 | JPOST Repository | Sun Oct 07 00:00:00 BST 2018

REPOSITORIES: jPOST

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Quantitative Proteomics of the Mitotic Chromosome Scaffold Reveals the Association of BAZ1B with Chromosomal Axes.

Ohta Shinya S Taniguchi Takako T Sato Nobuko N Hamada Mayako M Taniguchi Hisaaki H Rappsilber Juri J

Molecular & cellular proteomics : MCP 20180928 2

In mitosis, chromosomes achieve their characteristic shape through condensation, an essential process for proper segregation of the genome during cell division. A classical model for mitotic chromosome condensation proposes that non-histone proteins act as a structural framework called the chromosome scaffold. The components of the chromosome scaffold, such as DNA topoisomerase IIα (TOP2A) and structural maintenance of chromosomes protein 2 (SMC2), are necessary to generate stable mitotic chromo ...[more]

PMID: 30266865

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