Proteomics

Dataset Information

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Mouse liver and kidney proteome with antibiotics treatment

ABSTRACT: Dysbiosis (alteration of intestinal flora) is associated with various host physiologies, including diseases. The purpose of this study was to clarify the effect of dysbiosis on protein expression levels in mouse liver and kidney by quantitative proteomic analysis, focusing in particular on drug-metabolizing enzymes and transporters in order to investigate the potential impact of dysbiosis on drug pharmacokinetics.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Sumio Ohtsuki 

PROVIDER: PXD008237 | JPOST Repository | Mon Jan 01 00:00:00 GMT 2018

REPOSITORIES: jPOST

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Publications

Effect of Intestinal Flora on Protein Expression of Drug-Metabolizing Enzymes and Transporters in the Liver and Kidney of Germ-Free and Antibiotics-Treated Mice.

Kuno Takuya T   Hirayama-Kurogi Mio M   Ito Shingo S   Ohtsuki Sumio S  

Molecular pharmaceutics 20160720 8

Dysbiosis (alteration of intestinal flora) is associated with various host physiologies, including diseases. The purpose of this study was to clarify the effect of dysbiosis on protein expression levels in mouse liver and kidney by quantitative proteomic analysis, focusing in particular on drug-metabolizing enzymes and transporters in order to investigate the potential impact of dysbiosis on drug pharmacokinetics. Germ-free (GF) mice and antibiotics-treated mice were used as dysbiosis models. Ex  ...[more]

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