Proteomics

Dataset Information

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Mitotic chromosome scaffold SMC2ON vs OFF

ABSTRACT: Quantitative proteomics analysis of mitotic chromosome scaffold based on SILAC

ORGANISM(S): Gallus Gallus

SUBMITTER: SHINYA OHTA 

PROVIDER: PXD008429 | JPOST Repository | Sun Oct 07 00:00:00 BST 2018

REPOSITORIES: jPOST

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Publications

Quantitative Proteomics of the Mitotic Chromosome Scaffold Reveals the Association of BAZ1B with Chromosomal Axes.

Ohta Shinya S   Taniguchi Takako T   Sato Nobuko N   Hamada Mayako M   Taniguchi Hisaaki H   Rappsilber Juri J  

Molecular & cellular proteomics : MCP 20180928 2

In mitosis, chromosomes achieve their characteristic shape through condensation, an essential process for proper segregation of the genome during cell division. A classical model for mitotic chromosome condensation proposes that non-histone proteins act as a structural framework called the chromosome scaffold. The components of the chromosome scaffold, such as DNA topoisomerase IIα (TOP2A) and structural maintenance of chromosomes protein 2 (SMC2), are necessary to generate stable mitotic chromo  ...[more]