Proteomics

Dataset Information

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PRM of DMXAA-treated Raw264.7 secretome

ABSTRACT: Raw264.7 cells were cultured in serum-free DMEM containing DMSO or DMXAA for 4 h, and the conditioned media were collected. The precipitated proteins were directly digested with trypsin/Lys-C mix. Three biological replicates of the samples were individually prepared and analyzed by targeted LC-MS/MS using parallel reaction monitoring (PRM).

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Hidetaka Kosako 

PROVIDER: PXD009170 | JPOST Repository | Wed Apr 04 00:00:00 GMT+01:00 2018

REPOSITORIES: jPOST

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Dataset's files

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Action DRS
101_prm_motani_secretome_1_minus.raw Raw
103_prm_motani_secretome_3_minus.raw Raw
105_prm_motani_secretome_5_minus.raw Raw
107_prm_motani_secretome_2_plus.raw Raw
109_prm_motani_secretome_4_plus.raw Raw
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Publications

Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D.

Motani Kou K   Kosako Hidetaka H  

The Journal of biological chemistry 20180404 20

Stimulator of interferon genes (STING) is an endoplasmic reticulum-resident membrane protein that mediates cytosolic pathogen DNA-induced innate immunity and inflammatory responses in host defenses. STING is activated by cyclic di-nucleotides and is then translocated to the Golgi apparatus, an event that triggers STING assembly with the downstream enzyme TANK-binding kinase 1 (TBK1). This assembly leads to the phosphorylation of the transcription factor interferon regulatory factor 3 (IRF3), whi  ...[more]

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