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Proteome analysis of human serum from the esophageal cancer patient before preoperative chemoradiotherapy

ABSTRACT: To identify a biomarker that can predict the response of preoperative chemoradiotherapy (PCRT). Twenty-five serum samples from patents with esophageal cancer before PCRT (responder = 13, non-responder = 12) were analyzed by quantitative proteomics.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Sumio Ohtsuki

PROVIDER: PXD012819 | JPOST Repository | Fri Feb 21 00:00:00 GMT 2020

REPOSITORIES: jPOST

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Leucine-Rich Alpha-2-Glycoprotein 1 in Serum Is a Possible Biomarker to Predict Response to Preoperative Chemoradiotherapy for Esophageal Cancer.

Nambu Madoka M Masuda Takeshi T Ito Shingo S Kato Ken K Kojima Takashi T Daiko Hiroyuki H Ito Yoshinori Y Honda Kazufumi K Ohtsuki Sumio S

Biological & pharmaceutical bulletin 20190101 10

The purpose of the present study was to identify a biomarker that can predict the response to preoperative chemoradiotherapy (PCRT) in esophageal cancer patients. Twenty-five serum samples collected from patents with esophageal cancer before PCRT (responder = 13, non-responder = 12) were analyzed by quantitative proteomics, and 248 proteins were identified. Among them, the serum levels of leucine-rich alpha-2-glycoprotein 1 (LRG1) were significantly different (p < 0.01) and well discriminated (a ...[more]

PMID: 31582665

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