Egg-coat degradation
Ontology highlight
ABSTRACT:
ORGANISM(S): Gallus Gallus
SUBMITTER: Tsukasa Matsuda
PROVIDER: PXD013994 | JPOST Repository | Thu Aug 01 00:00:00 BST 2019
REPOSITORIES: jPOST
Publications
Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility.
Nishimura Kaoru K Dioguardi Elisa E Nishio Shunsuke S Villa Alessandra A Han Ling L Matsuda Tsukasa T Jovine Luca L
Nature communications 20190712 1
Mammalian fertilisation begins when sperm interacts with the egg zona pellucida (ZP), whose ZP1 subunit is important for fertility by covalently cross-linking ZP filaments into a three-dimensional matrix. Like ZP4, a structurally-related component absent in the mouse, ZP1 is predicted to contain an N-terminal ZP-N domain of unknown function. Here we report a characterisation of ZP1 proteins carrying mutations from infertile patients, which suggests that, in human, filament cross-linking by ZP1 i ...[more]
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