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Proteomic identification of the proteins that co-precipitated with FUT8

ABSTRACT: Essential roles of FUT8 SH3 domain in core fucosylation

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Miyako Nakano

PROVIDER: PXD018032 | JPOST Repository | Wed Apr 29 00:00:00 BST 2020

REPOSITORIES: jPOST

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The SH3 domain in the fucosyltransferase FUT8 controls FUT8 activity and localization and is essential for core fucosylation.

Tomida Seita S Takata Misaki M Hirata Tetsuya T Nagae Masamichi M Nakano Miyako M Kizuka Yasuhiko Y

The Journal of biological chemistry 20200429 23

Core fucose is an <i>N</i>-glycan structure synthesized by α1,6-fucosyltransferase 8 (FUT8) localized to the Golgi apparatus and critically regulates the functions of various glycoproteins. However, how FUT8 activity is regulated in cells remains largely unclear. At the luminal side and uncommon for Golgi proteins, FUT8 has an Src homology 3 (SH3) domain, which is usually found in cytosolic signal transduction molecules and generally mediates protein-protein interactions in the cytosol. However, ...[more]

PMID: 32350116

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