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KT01_b: The Bartonella autotransporter BafA mimics host VEGF to drive angiogenesis. Wild type.

ABSTRACT: The Bartonella autotransporter BafA mimics host VEGF to drive angiogenesis. Wild type.

ORGANISM(S): Bartonella Henselae Str. Houston-1

SUBMITTER: Kentaro Tsukamoto

PROVIDER: PXD018354 | JPOST Repository | Wed Jun 10 00:00:00 BST 2020

REPOSITORIES: jPOST

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The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis.

Tsukamoto Kentaro K Shinzawa Naoaki N Kawai Akito A Suzuki Masahiro M Kidoya Hiroyasu H Takakura Nobuyuki N Yamaguchi Hisateru H Kameyama Toshiki T Inagaki Hidehito H Kurahashi Hiroki H Horiguchi Yasuhiko Y Doi Yohei Y

Nature communications 20200716 1

Pathogenic bacteria of the genus Bartonella can induce vasoproliferative lesions during infection. The underlying mechanisms are unclear, but involve secretion of an unidentified mitogenic factor. Here, we use functional transposon-mutant screening in Bartonella henselae to identify such factor as a pro-angiogenic autotransporter, called BafA. The passenger domain of BafA induces cell proliferation, tube formation and sprouting of microvessels, and drives angiogenesis in mice. BafA interacts wit ...[more]

PMID: 32678094

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