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Identification and quantification of cholangiocarcinoma (CCA) marker proteins from bile extracellular vesicles for non-invasive diagnosis

ABSTRACT: Extracellular vesicles (EVs) including exosomes are secreted into extracellular fluids, which are found in most body fluids. Since EVs contain a number of biologically active molecules such as proteins and mRNAs, there has been increasing interest in EVs as a carrier of potential biomarkers for various diseases. We previously reported that chelating reagent enhanced the recovery rate of EVs from serum, plasma, and urine. In this study, we used bile EVs which packaged biomarker molecules secreted from CCA lesion. Then we performed proteomic analysis of EVs isolated from human bile in CCA and choledocholithiasis (biliary stone) for CCA biomarkers discovery.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Kazuya Omi

PROVIDER: PXD020349 | JPOST Repository | Wed Jul 14 00:00:00 BST 2021

REPOSITORIES: jPOST

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Circulating extracellular vesicles with liver-specific RNA species are potential biomarkers for early cholestasis-induced liver fibrosis [mRNA-seq]

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Circulating extracellular vesicles with liver-specific RNA species are potential biomarkers for early cholestasis-induced liver fibrosis [RNA-seq]

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2021-09-09 | PXD019924 | Pride

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