Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Xiaosai Yao
PROVIDER: PXD020554 | JPOST Repository | Sat Jul 24 00:00:00 BST 2021
REPOSITORIES: jPOST
Yao Xiaosai X Hong Jing Han JH Nargund Amrita M AM Ng Michelle Shu Wen MSW Heng Hong Lee HL Li Zhimei Z Guan Peiyong P Sugiura Masahiro M Chu Pek Lim PL Wang Loo Chien LC Ye Xiaofen X Qu James J Kwek Xiu Yi XY Lim Jeffrey Chun Tatt JCT Ooi Wen Fong WF Koh Joanna J Wang Zhenxun Z Pan You-Fu YF Ong Yan Shan YS Tan Kiat-Yi KY Goh Jian Yuan JY Ng Sheng Rong SR Pignata Luca L Huang Dachuan D Lezhava Alexander A Tay Su Ting ST Lee Minghui M Yeo Xun Hui XH Tam Wai Leong WL Rha Sun Young SY Li Shang S Guccione Ernesto E Futreal Andrew A Tan Jing J Yeong Joe Poh Sheng JPS Hong Wanjin W Yauch Robert R Chang Kenneth Tou-En KT Sobota Radoslaw M RM Tan Patrick P Teh Bin Tean BT
Nature cell biology 20230424 5
PBRM1 encodes an accessory subunit of the PBAF SWI/SNF chromatin remodeller, and the inactivation of PBRM1 is a frequent event in kidney cancer. However, the impact of PBRM1 loss on chromatin remodelling is not well examined. Here we show that, in VHL-deficient renal tumours, PBRM1 deficiency results in ectopic PBAF complexes that localize to de novo genomic loci, activating the pro-tumourigenic NF-κB pathway. PBRM1-deficient PBAF complexes retain the association between SMARCA4 and ARID2, but h ...[more]