Identification of the components of PRDM14 complex in ESCs
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Yoshiyuki Seki
PROVIDER: PXD020571 | JPOST Repository | Mon Aug 03 00:00:00 BST 2020
REPOSITORIES: jPOST
Publications
The PRDM14-CtBP1/2-PRC2 complex regulates transcriptional repression during the transition from primed to naïve pluripotency.
Yamamoto Maiko M Suwa Yoshiaki Y Sugiyama Kohta K Okashita Naoki N Kawaguchi Masanori M Tani Naoki N Matsubara Kazumi K Nakamura Akira A Seki Yoshiyuki Y
Journal of cell science 20200814 15
The pluripotency-associated transcriptional network is regulated by a core circuitry of transcription factors. The PR domain-containing protein PRDM14 maintains pluripotency by activating and repressing transcription in a target gene-dependent manner. However, the mechanisms underlying dichotomic switching of PRDM14-mediated transcriptional control remain elusive. Here, we identified C-terminal binding protein 1 and 2 (CtBP1 and CtBP2; generically referred to as CtBP1/2) as components of the PRD ...[more]
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